Figure 2.

Development of human breast carcinoma is characterized by abundant infiltration of lymphocytes into neoplastic tissue. Representative sections of normal, premalignant, and malignant breast assessed for the presence of CD4+ (upper panels) and CD8+ (middle panels) T lymphocytes (brown staining in panels), as well as CD20+ B lymphocytes (red staining in lower panels), demonstrating the extent of immune-cell infiltration into premalignant and malignant stroma. DCIS, ductal carcinoma in situ.

DeNardo and Coussens Breast Cancer Research 2007 9:212   doi:10.1186/bcr1746
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