Overall survival of breast cancer patients with regard to c-erbB2 and topoisomerase IIα protein expression. (a) Patients with (solid line) or without (dashed line) c-erbB2 protein overexpression. The difference was significant in univariate statistical analysis (log rank 17.94; P < 0.0001). (b) Significant difference of survival time of patients with tumors positive for topoisomerase IIα protein in more than 25% of tumor cells (solid line) versus patients with tumors with less than 25% topoisomerase IIα-positive cells (dashed line) (log rank 15.59; P = 0.0001).
Fritz et al. Breast Cancer Research 2005 7:R374-R384 doi:10.1186/bcr1012