E-cadherin expression at the primary and distant metastatic sites. (A) and (B) Primary invasive ductal carcinoma with aberrant (reduced) E-cadherin expression. (C) This tumor metastasized 3 years later to the iliac bone. The metastatic carcinoma cells express normal levels of E-cadherin (re-expression). 200 × magnification.
Kowalski et al. Breast Cancer Res 2003 5:R217-R222 doi:10.1186/bcr651