Email updates

Keep up to date with the latest news and content from Breast Cancer Research and BioMed Central.

Highly Accessed Open Badges Editorial

Migratory gene expression signature predicts poor patient outcome: Are cancer stem cells to blame?

Max S Wicha

Author Affiliations

University of Michigan Comprehensive Cancer Center, 6302 CC, 1500 E. Medical Center Dr., Ann Arbor, MI 48109-5942, USA

Breast Cancer Research 2012, 14:114  doi:10.1186/bcr3338

See related research by Patsialou et al.,

Published: 15 November 2012


Breast cancer metastasis accounts for the majority of deaths from this disease. In the previous issue of Breast Cancer Research, Patsialou and colleagues used a novel in vivo invasion assay to capture migrating breast cancer cells and demonstrate that the gene expression signature of these cells predicts breast cancer metastasis in a large cohort of patients. Furthermore, specific genes identified play a functional role in the invasion of MDA-MB-231 breast cancer cells and in patient-derived breast tumors. These genes regulate pathways known to be induced in invasion and metastases and play an important role in the regulation of cancer stem cells.