Migratory gene expression signature predicts poor patient outcome: Are cancer stem cells to blame?
University of Michigan Comprehensive Cancer Center, 6302 CC, 1500 E. Medical Center Dr., Ann Arbor, MI 48109-5942, USA
Breast Cancer Research 2012, 14:114 doi:10.1186/bcr3338
See related research by Patsialou et al., http://breast-cancer-research.com/content/14/5/R139Published: 15 November 2012
Breast cancer metastasis accounts for the majority of deaths from this disease. In the previous issue of Breast Cancer Research, Patsialou and colleagues used a novel in vivo invasion assay to capture migrating breast cancer cells and demonstrate that the gene expression signature of these cells predicts breast cancer metastasis in a large cohort of patients. Furthermore, specific genes identified play a functional role in the invasion of MDA-MB-231 breast cancer cells and in patient-derived breast tumors. These genes regulate pathways known to be induced in invasion and metastases and play an important role in the regulation of cancer stem cells.