Additional file 3.

Potential Mechanisms Linking Runx2 to SNAI2. Based on the observation that Runx2 down-regulated expression of SPDEF and strong occupancy of the SPDEF transcription start site by Runx2 we hypothesize that Runx2 indirectly stimulates SNAI2 expression in part via modulation of ETS signaling.

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Chimge et al. Breast Cancer Research 2011 13:R127   doi:10.1186/bcr3073