Oral α-tocopheryloxyacetic acid (α-TEA) decreases breast tumor growth and prolongs survival. BALB/c mice with established 4T1 mammary tumors (day 10, ~15 mm2) received oral α-TEA in their diet (~6 mg/day, equivalent to 300 mg/kg body wt) or a nutrient-matched control diet. (A) Individual tumor areas. (B) Mean tumor areas ± SEM (n = 10 mice per group). Difference in average tumor area first reaches significance on day 18 posttumor area (dotted line). (C) Kaplan-Meier analysis of survival.
Hahn et al. Breast Cancer Research 2011 13:R4 doi:10.1186/bcr2808