Figure 1.

Histological grade of breast cancer as assessed by the Nottingham Grading System. (a) A well-differentiated tumor (grade 1) that demonstrates high homology to the normal breast terminal duct lobular unit, tubule formation (>75%), a mild degree of nuclear pleomorphism, and low mitotic count. (b) A moderately differentiated tumor (grade 2). (c) A poorly differentiated (grade 3) tumor with a marked degree of cellular pleomorphism and frequent mitoses and no tubule formation (<10%).

Rakha et al. Breast Cancer Research 2010 12:207   doi:10.1186/bcr2607
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